Detalhe da pesquisa
1.
A bromodomain-independent mechanism of gene regulation by the BET inhibitor JQ1: direct activation of nuclear receptor PXR.
Nucleic Acids Res
; 52(4): 1661-1676, 2024 Feb 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38084912
2.
Structure-guided approach to modulate small molecule binding to a promiscuous ligand-activated protein.
Proc Natl Acad Sci U S A
; 120(10): e2217804120, 2023 03 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-36848571
3.
Crystal structure of human Cep57 C-terminal domain reveals the presence of leucine zipper and the potential microtubule binding region.
Proteins
; 2024 May 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38699879
4.
Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation.
Nucleic Acids Res
; 50(6): 3254-3275, 2022 04 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35212371
5.
Water Networks Repopulate Protein-Ligand Interfaces with Temperature.
Angew Chem Int Ed Engl
; 61(31): e202112919, 2022 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35648650
6.
The genome of a Bacteroidetes inhabitant of the human gut encodes a structurally distinct enoyl-acyl carrier protein reductase (FabI).
J Biol Chem
; 295(22): 7635-7652, 2020 05 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-32317282
7.
Unraveling the Structural Basis of Selective Inhibition of Human Cytochrome P450 3A5.
J Am Chem Soc
; 143(44): 18467-18480, 2021 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34648292
8.
Structures of human phosphofructokinase-1 and atomic basis of cancer-associated mutations.
Nature
; 523(7558): 111-4, 2015 Jul 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-25985179
9.
Expression system for structural and functional studies of human glycosylation enzymes.
Nat Chem Biol
; 14(2): 156-162, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29251719
10.
Mitochondrial COQ9 is a lipid-binding protein that associates with COQ7 to enable coenzyme Q biosynthesis.
Proc Natl Acad Sci U S A
; 111(44): E4697-705, 2014 Nov 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-25339443
11.
Dimerization of VirD2 binding protein is essential for Agrobacterium induced tumor formation in plants.
PLoS Pathog
; 10(3): e1003948, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24626239
12.
Design of activated serine-containing catalytic triads with atomic-level accuracy.
Nat Chem Biol
; 10(5): 386-91, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24705591
13.
Two Fe-S clusters catalyze sulfur insertion by radical-SAM methylthiotransferases.
Nat Chem Biol
; 9(5): 333-8, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23542644
14.
Enzymatic basis for N-glycan sialylation: structure of rat α2,6-sialyltransferase (ST6GAL1) reveals conserved and unique features for glycan sialylation.
J Biol Chem
; 288(48): 34680-98, 2013 Nov 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-24155237
15.
Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR.
Nat Commun
; 15(1): 4054, 2024 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38744881
16.
Structural and biochemical characterization of the bilin lyase CpcS from Thermosynechococcus elongatus.
Biochemistry
; 52(48): 8663-76, 2013 Dec 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-24215428
17.
Computational design of an unnatural amino acid dependent metalloprotein with atomic level accuracy.
J Am Chem Soc
; 135(36): 13393-9, 2013 Sep 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-23924187
18.
Crystal structure of a catalytically active GG(D/E)EF diguanylate cyclase domain from Marinobacter aquaeolei with bound c-di-GMP product.
J Struct Funct Genomics
; 13(3): 177-83, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22843345
19.
Three structural representatives of the PF06855 protein domain family from Staphyloccocus aureus and Bacillus subtilis have SAM domain-like folds and different functions.
J Struct Funct Genomics
; 13(3): 163-70, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22843344
20.
Solution NMR and X-ray crystal structures of Pseudomonas syringae Pspto_3016 from protein domain family PF04237 (DUF419) adopt a "double wing" DNA binding motif.
J Struct Funct Genomics
; 13(3): 155-62, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22865330